Ttp thrombotic thrombocytopaenic purpura
title: Thrombotic Thrombocytopaenic Purpura tags: #FFICM notebook: 🌑-FFICM type: inprogress
source: mcqs-and-sbas-in-intensive-care-medicine-oxford-higher-special-training
| Flashcard | type:basic |
|---|---|
| What does TTP stand for? | Thrombotic Thrombocytopaenic Purpura |
| What is the immunological cause of TTP? | Autoantibodies against ADAMTS13 |
| What is ADAMTS13 for? | Splitting up von Willebrand Factor |
| What is the name of the enzyme that splits up von Willebrand Factor? | ADAMTS13 |
| What is the enzyme that's attacked by the body, to result in the illness TTP? | ATAMTS13 |
| What type of anaemia do you get in TTP? | A haemolytic anaemia |
| Will you have high conjugated or uncongugated bilirubin in TTP? | Unconjugated (it's a haemolytic anaemia) |
| Do your levels of ADAMTS13 go up or down in TTP? | Down |
| What level of activity does your ADAMTS13 reach in TTP? | Less than 10% |
| What happens to your complement levels in TTP? | They stay the same |
| What is the main treatment for TTP? | Plasma Exchange |
| If you see someone with microangiopathic haemolysis, and low platelets, what disease should you think of? | TTP |
| Which haem illness has the classic pentad of features? | TTP |
Cloze stuff:
| Flashcard | type:cloze |
|---|---|
| {{c1::TTP}} is a pentad of {{c2::thrombocytopaenia}} {{c3::AKI}} {{c4::neurological involvement}} {{c5::anaemia (MAHA)}} {{c6::fever}} |