Digoxin
title: Digoxin tags: #FFICM notebook: 🌑-FFICM type: inprogress
source: mcqs-and-sbas-in-intensive-care-medicine-oxford-higher-special-training
| Flashcard | type:basic |
|---|---|
| What class of drugs is digoxin? | A glycoside |
| What is the target of action of digoxin? | It inhibits Na+/K+ ATPase |
| How does digoxin interact with Na/K ATPase? | It inhibits it |
| When digoxin inhibits Na/K ATPase, what cellular changes does that cause? | It increases intracellular calcium |
| How does digoxin increase inotropy of cardiac cells? | It increases intracellular calcium by blocking Na/K ATPasa |
| Does digoxin increase or decrease cardiac inotropy? | Increase |
| Does digoxin increase or decrease acetylcholine at muscarinic receptors? | Increase |
| Does digoxin increase or decrease Na/K ATPase activity? | Decrease |
| Does digoxin increase or decrease intracellular calcium levels in heart? | Increase |
| Does digoxin speed up or slow down conduction in the heart? | Slows down |
| What does digoxin do to conduction in the heart's speed? | Slows it down |
| How does digoxin slow down conduction within the heart? | It increases acetylcholine at muscarinic receptors |
| Which receptors does digoxin change the levels of acetylcholine at? | The muscarinic receptors |
| Does digoxin act on nicotinic or muscarinic receptors? | Muscarinic |
| Is digoxin made worse by hyper or hypokalaemia? | Hypokalaemia |
| Does digoxin cause hyper or hypokalaemia? | Hyperkalaemia |
| How high a digoxin level is toxic? | > 2.5 microgram/l |
| How high a digoxin level is severely toxic? | > 20 microgram/l |
| When should you give digibind for digoxin toxicity? | When digoxin level is greater than 20 |
| Can adenosine cardiovert any dysrhythmia? | Yes, when there is a AVNRT |
| What dysrhythmia can adenosine cardiovert? | AVNRT (AV Nodal Re Entrant Tachycardia) |
| Can adenosine cardiovert AVNRT? | Yes |
| Can adenosine cardiovert AF? | No |
| Can adenosine cardiovert Atrial Fibrillation? | No |