Wed17November0747PM 5

True / False

Bolus is associated with a transient decrease in ventilation Correct

Action is reversed by the administration of naloxone Correct

Can be safely used in acute renal failure since its conjugated metabolites are inactive Incorrect answer selected

Has anticholinergic properties Correct

Use is associated with a loss of the light reflex Correct

Explanation

Norketamine is the conjugated metabolite of ketamine. It has 20-30% of the activity of the parent compound.

Although ketamine is thought to interact with opioid receptors, naloxone does not reverse the analgesic effect of the drug.

Ketamine antagonises muscarinic and nicotinic receptors.

The light reflex is not lost.

Further Reading:

Pai A, Heining M. Ketamine. Contin Educ Anaesth Crit Care Pain. 2007;7:59-63.

Answer Statistics

Not enough data to display the statistics

Average score: 59.75%

Times answered: 244