Wed13October0734AM 4

Low plasma cholinesterase activity is associated with:

True / False

Organophosphorus insecticide poisoning Correct

Thyrotoxicosis Incorrect answer selected

Liver disease Correct

Iron deficiency anaemia Correct

Obesity Incorrect answer selected

Explanation

Plasma cholinesterase is a glycoprotein enzyme that is manufactured in the liver and is responsible for the metabolism of suxamethonium, mivacurium, procaine and cocaine. A deficiency can be genetic or acquired.

Low plasma cholinesterase deficiency is associated with:

Liver disease

Renal disease

Malnutrition

Pregnancy

Malignancy (especially liver, lung and gastrointestinal)

Cardiopulmonary bypass

Leprosy

Burns

Hypothyroidism and hyperthyroidism

Non-competitive cholinesterase inhibitors (ecothiopate and organophosphorous insecticides), and

Competitive cholinesterase inhibitors (anticholinesterases, cocaine, oral contraceptives, monamine oxidase inhibitors, aspirin and metoclopramide).

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Average score: 69.13%

Times answered: 254