Wed13October0734AM 2

True / False

May cause hypothyroidism and hyperthyroidism Correct

Is used to treat Wolff-Parkinson-White syndrome Incorrect answer selected

Prolongs the refractory period Correct

Is poorly protein bound Correct

Prolongs the QT interval Correct

Explanation

Amiodarone is an antiarrhythmic drug used to treat ventricular tachycardia, supraventricular tachycardia and Wolff-Parkinson-White syndrome. It is highly protein bound. It has numerous side effects including hyperthyroidism and hypothyroidism, pneumonitis and hepatitis.

Amiodarone belongs to class III of the Vaughan-Williams classification of antiarrhythmic drugs. It prolongs the action potential and refractory period due to its blocking action on potassium channels. This blockade slows phase 3 repolarisation. It may also prolong the QT interval.

Reference:

Peck TE, Hill S. Pharmacology for Anaesthesia and Intensive Care. 3rd ed. Cambridge: Cambridge University Press; 2008.

Answer Statistics

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Average score: 79.92%

Times answered: 238