Wed10November0747AM 4

Is it true that complications of tumour lysis syndrome include the following?

True / False

Hypernatraemia Correct

Hyperphosphataemia Correct

Hypokalaemia Correct

Hyperuricaemia Correct

Hypercalcaemia Incorrect answer selected

Explanation

Tumour lysis syndrome (TLS) is a life threatening complication that arises when the rapid lysis of tumour cells leads to the release of excessive quantities of cellular contents into the systemic circulation resulting in a metabolic disturbance characterised by:

Hyperkalaemia

Hyperphosphataemia

Hyperuricaemia, and

Hypocalcaemia (because of the hyperphosphataemia, calcium is precipitated to form calcium phosphate, leading to hypocalcaemia).

This metabolic derangement may lead to acute oliguric renal failure and cardiac arrhythmias.

Sodium is a major extracellular ion and hence hypernatraemia is not a metabolic complication of TLS.

Reference:

Beed M, Levitt M, Bokhari SW. Intensive care management of patients with haematological malignancy. Contin Educ Anaesth Crit Care Pain. 2010;10:167-171.

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Times answered: 257