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True / False

Is a modified gamma cyclodextrin Correct

It reverses rocuronium by an encapsulation mechanism Correct

Can be used to reverse vecuronium Correct

Has a slow reversal activity when compared to neostigmine Correct

Can be used in both adult and paediatric anaesthesia Correct

Explanation

Sugammadex (Bridion), a modified gamma-cyclodextrin, is the first selective relaxant binding agent indicated to reverse the neuromuscular blockade induced during general anaesthesia to facilitate surgical procedures. The mechanism of action of sugammadex differs from that of other commonly used reversal agents, such as neostigmine and edrophonium.

In the European Union, sugammadex is recommended for use in the reversal of rocuronium- or vecuronium-induced moderate or deep muscle relaxation in adult (including elderly) patients and reversal of rocuronium-induced moderate muscle relaxation in paediatric patients.

Mechanism of action of sugammadex is to encapsulate rocuronium to provide for a rapid reversal of residual neuromuscular blockade.

Reference:

Sacan O, White PF, Tufanogullari B, Klein K. Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine. Anesth Analg. 2007;104:569-74.

Yang LP, Keam SJ. Sugammadex: a review of its use in anaesthetic practice. Drugs. 2009;69:919-42.

Answer Statistics

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Average score: 89.45%

Times answered: 218