Thu18November0253AM 3

Which of the following stimulate the generation of cyclic AMP as the second messenger?

(Please select 1 option)

Tissue Necrosis Factor (TNF) alpha

Growth hormone

Pioglitazone

Nitric Oxide Incorrect answer selected

Cholera toxin This is the correct answer

Explanation

Nitric oxide generates cyclic guanosine monophosphate (cGMP) as the second messenger and pioglitazone acts through agonism of peroxisome proliferator activating receptor (PPAR) gamma.

Calcitonin cholera toxin binds to the ganglioside receptors and causes excessive production of cyclic adenosine monophosphate (cAMP) which leads to the activation of luminal sodium pumps and the secretory diarrhoea.

GH like TNF alpha acts on the GH/cytokine superfamily of receptors which function via the janus kinases/signal transducers and activators of transcription (JAK-STAT) pathway.

Answer Statistics

1

7%

2

27%

3

3%

4

46%

5

19%

Times answered: 252