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The use of mannitol is associated with a reduction in the incidence of acute renal failure in patients with:

True / False

Rhabdomyolysis Correct

Hepatorenal syndrome Correct

Sepsis Correct

Aortic aneurysm repair Correct

Renal transplantation Incorrect answer selected

Explanation

Mannitol has the potential to protect vulnerable kidneys.

As a freely filtered molecule it remains within the renal tubules and prompts an osmotic dieresis that may 'flush' out toxic waste products. Mannitol, through a number of mechanisms, also increases renal blood flow and acts as a free radical scavenger.

However evidence to support the use of mannitol is limited. Importance should be placed instead upon adequate hydration and other supportive measures.

Reference:

Shawkat H, Westwood MM, Mortimer A. Mannitol: a review of its clinical uses. Contin Educ Anaesth Crit Care Pain. 2012;12:82-85.

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Times answered: 238