Thu11November0627PM 7

Is it true or false that acute pancreatitis is a recognised complication of the following?

True / False

Gentamicin therapy Correct

Thiazide diuretics Correct

Abdominal radiotherapy Correct

Cytotoxic chemotherapy Correct

Steroid therapy Correct

Explanation

Drugs associated with pancreatitis include:

Steroids

Oestrogens

Thiazides

Valproate, and

Azathioprine.

The most notable precipitant is alcohol.

Chemotherapy with cisplatin/vinca alkaloids1 may produce acute pancreatitis.

Radiotherapy is not associated with acute but is associated with chronic pancreatitis2.

Reference:

Wilmink T, Frick TW. Drug-induced pancreatitis. Drug Saf. 1996;14(6):406-23.

Lévy P, Menzelxhiu A, Paillot B, et al. Abdominal radiotherapy is a cause for chronic pancreatitis. Gastroenterology. 1993;105(3):905-9.

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