Sun28November0628PM 18

King's College criteria for potential liver transplant following a paracetamol overdose include:

True / False

Bilirubin >120 µmol/L Correct

INR >5 Correct

Serum creatinine >300 µmol/L Correct

Pre-existing cirrhosis Correct

pH <7.3 Correct

Explanation

King's College Hospital criteria following paracetamol overdose includes:

pH <7.3 (or <7.25 if previously given N-acetyl cysteine)

Grade III-IV encephalopathy

Creatinine > 300 µmol/L, and

INR >6.5.

Different criteria existing for non-paracetamol induced liver failure.

The Child-Pugh utilises the bilirubin level, albumin, INR, presence of ascites and encephalopathy whilst the MELD score calculation uses bilirubin, INR and creatinine. There is also a Glasgow score of alcoholic hepatitis.

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