Sun28November0440PM 39

Are the following true or false of anticholinergic drugs?

True / False

May decrease the tone of the lower oesophageal sphincter Correct

May produce bronchoconstriction Correct

May produce amnesia Correct

All cross blood-brain barrier Correct

Act on muscarinic receptors of acetylcholine Correct

Explanation

Anticholinergic drugs act on muscarinic receptors for which acetylcholine is an agonist. They include atropine, glycopyrrolate and hyoscine. These drugs have the potential to cause bronchodilation.

Both atropine and hyoscine are tertiary amines and have the potential to cross the placenta and blood-brain barrier (BBB) to produce central effects. Hyoscine has the potential to produce amnesia. Glycopyrrolate is a quaternary amine and cannot cross the placenta and the BBB.

Anticholinergic agents may decrease the tone of the lower oesophageal sphincter

Reference:

Peck TE, Hill SA, Williams M. Pharmacology for Anaesthesia and Intensive Care. 3rd ed. Edinburgh: Cambridge University Press; 2008.

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