Sun28November0440PM 15

The following drugs can cause serotonin syndrome:

True / False

Amitryptiline Correct

Fluoxetine Correct

Tramadol Correct

Venlafaxine Correct

St John's Wort Correct

Explanation

Serotonin syndrome is the result of over stimulation of serotonin (5-HT) receptors in the brain. It is typically caused by the combination of two or more drugs however it can occur following initiation of a new drug or a change of dose.

All of the drugs in this question have serotonergic properties and can therefore trigger symptoms and signs.

Further Reading:

Chinniah S, French JLH, Levy DM. Serotonin and anaesthesia. Contin Educ Anaesth Crit Care Pain. 2008;8:43-45.

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Average score: 78.95%

Times answered: 266