Sun28November0333PM 5

Are the following true regarding 1,25(OH)2 vitamin D?

True / False

Promotes phosphate and calcium absorption from the gut Correct

Attaches to cytosolic receptors Correct

25 hydroxylation occurs in the kidney Correct

Release is stimulated by hypophosphataemia Correct

Concentrations are increased in chronic renal failure Correct

Explanation

25 hydroxylation occurs in the liver. 1 hydroxylation is in the kidney.

Hypophosphataemia and hypocalcaemia are the main stimulants of 1 alpha hydroxylation.

1,25(OH)2 vitamin D attaches to cytosolic receptors like a classic steroid hormone.

Concentrations of 1,25(OH)2 vitamin D are decreased in chronic renal failure

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