Sun17October0936AM 3

True / False

Is structurally related to vecuronium Correct

Onset of action is quicker by increasing the dose Correct

Can cause anaphylaxis Correct

Has a specific reversal agent Correct

Is an aminosteroid compound Correct

Explanation

Rocuronium is an aminosteroid compound developed from vecuronium. It has a rapid onset of action of 60-90 seconds due to its low potency. This can be further reduced to 60 seconds at a dose of 0.9-1.2 mg/kg.

It can cause anaphylaxis.

Rocuronium is minimally metabolised and is excreted mostly unchanged in the urine. Sugammadex is a gamma cyclodextrin that encapsulates the rocuronium compound and reverses the neuromuscular blockade.

Reference:

Peck TE, Hill SA, Williams M. Pharmacology for Anaesthesia and Intensive Care. 3rd ed. Edinburgh: Cambridge University Press; 2008.

Sasada M, Smith S. Drugs in Anaesthesia & Intensive Care. 3rd ed. New York: Oxford University Press; 2010.

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Average score: 91.71%

Times answered: 234