Sun17October0644AM 10

Are the following true or false of spironolactone?

True / False

Hyperkalaemia may occur Correct

It is a competitive aldosterone antagonist Correct

Gynaecomastia is a recognised side effect Correct

Hypernatraemia may occur Correct

Uses include management of alcohol induced ascites Correct

Explanation

Spironolactone is available as an oral preparation diuretic.

It is a competitive aldosterone antagonist. By inhibiting aldosterone, sodium influx or potassium excretion is prevented, thus having the potential to cause hyponatraemia and hyperkalaemia.

Its diuretic action makes it ideal for treating ascites of chronic liver disease and it is also licensed for chronic heart failure. Due to its chemical structure it has anti-androgen side effects leading to gynaecomastia.

Reference:

Medicines Complete. Spironolactone.

NICE. Chronic heart failure (CG108).

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