Sun14November1246PM 9

Which of the following reactions is involved in the metabolism of paracetamol under normal conditions?

(Please select 1 option)

Acetylation

Hydrolysis

Cytochrome p450 dependent oxidation

Conjugation to glucuronic acid This is the correct answer

Conjugation to glutathione Incorrect answer selected

Explanation

Paracetamol is conjugated to glucuronic acid and sulphate under normal conditions.

In overdose these processes become saturated and the drug is then conjugated with glutathione.

If the glutathione supply is depleted then a toxic metabolite is formed.

https://sepia.unil.ch/pharmacology/index.php?id=87

Answer Statistics

1

12%

2

1%

3

8%

4

27%

5

54%

Times answered: 249