Sun14November1246PM 38

Are the following true or false of the anticholinergic drugs hyoscine hydrobromide, atropine and glycopyrrolate?

True / False

They have high level of activity at nicotinic receptors Correct

Hyoscine hydrobromide use may precipitate excitement and ataxia Correct

Glycopyrrolate has significant sedative effect Correct

Glycopyrrolate is a naturally occurring ester Incorrect answer selected

Atropine has the greatest antisialogogue properties Incorrect answer selected

Explanation

The anticholinergic agents hyoscine, atropine and glycopyrrolate act on muscarinic receptors with little activity at the nicotinic receptors.

Hyoscine and atropine are naturally occurring esters. Glycopyrrolate is a synthetic quaternary amine and therefore does not cross the blood brain barrier.

Hyoscine hydrobromide has the greatest antisialogogue properties. It may cause central anticholinergic syndrome as it readily crosses the blood brain barrier. It is characterised by hallucinations, excitement and ataxia.

Note, hyoscine butylbromide does not cross the blood brain barrier significantly.

Reference:

Peck TE, Hill SA, Williams M. Pharmacology for Anaesthesia and Intensive Care. 3rd ed. Edinburgh: Cambridge University Press; 2008.

Sasada M, Smith S. Drugs in Anaesthesia & Intensive Care. 3rd ed. New York: Oxford University Press; 2010.

Answer Statistics

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Average score: 75.29%

Times answered: 242