Sun14November1246PM 33

Are the following true or false of propofol?

True / False

Is 10% protein bound Correct

Is a phenol derivative Correct

Acts primarily as an antagonist at the NDMA receptor Correct

May cause urinary discolouration Correct

Is associated with malignant hyperthermia in susceptible patients Correct

Explanation

Propofol is a phenol derivative and its chemical structure is 2, 6 di-isopropylphenol. It is about 97% protein bound.

Propofol acts on the GABAA receptors and increases the duration of chloride channel opening.

It is not associated with malignant hyperthermia (MH) and is safe to use in MH susceptible patients.

It may cause green discolouration to urine and hair.

Reference:

Peck TE, Hill SA, Williams M. Pharmacology for Anaesthesia and Intensive Care. 3rd ed. Edinburgh: Cambridge University Press; 2008.

Sasada M, Smith S. Drugs in Anaesthesia & Intensive Care. 3rd ed. New York: Oxford University Press; 2010.

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