Sun14November1246PM 29

Is it true or false that the following may increase the duration of action of non-depolarising muscular blockers (NDMB)?

True / False

Calcium channel blockers Correct

Lithium Correct

Hypermagnesaemia Correct

Hypothermia Correct

Hypokalaemia Correct

Explanation

There are a number of physiological and pharmacological interactions with NDMB, prolonging their duration of action.

Hypokalaemia causes the resting membrane potential to be more negative, potentiating the effects of muscle relaxants.

Magnesium is a natural calcium antagonist and reduces the release of acetylcholine.

Hypothermia reduces the metabolism of muscle relaxants.

Lithium causes sodium channel blockade.

Calcium channel blockers reduce the release of acetylcholine by reducing calcium influx into the cells.

Reference:

Peck TE, Hill SA, Williams M. Pharmacology for Anaesthesia and Intensive Care. 3rd ed. Edinburgh: Cambridge University Press; 2008.

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