Sat27November0556PM 8

In relation to the diuretic effects of indapamide, which class of drug does its mechanism of action resemble?

(Please select 1 option)

Thiazide diuretic Correct

ACE-Inhibitor

Angiotensin Receptor Blocker (ARB's)

Loop diuretic

Osmotic diuretic

Explanation

Indapamide is a thiazide-like diuretic which is used in hypertension. Unlike the true thiazides, it does not possess the thiazide ring system in its chemical structure. Its clear mechanism is not fully understood but it blocks the passage of sodium and calcium across the cell membrane while causing smooth muscle relaxation and vasodilation.

Loop diuretics include furosemide and bumetanide and work on the thick ascending limb in the loop of Henle.

Osmotic diuretics such as Mannitol are used to reduce raised intracranial pressure.

ACE-inhibitors are first line in hypertension in caucasian patients under the age of 55.

ARBs are used in patients unable to tolerate ACE-inhibitors or other diuretics.

Answer Statistics

1

67%

2

2%

3

4%

4

25%

5

4%

Times answered: 263