Sat27November0445PM 46

Following an aspirin overdose, are the following statements true?

True / False

Fat metabolism is increased Correct

Initially a respiratory alkalosis is seen Correct

In the early stages hyperkalaemia is common Correct

A metabolic acidosis develops more commonly and rapidly in children Correct

Urinary pH is initially acidic Incorrect answer selected

Explanation

Aspirin (salicylates) directly stimulate the respiratory centre causing an initial respiratory alkalosis.

The excretion of bicarbonate, potassium and water is increased which results in hypokalaemia (not hyperkalaemia), dehydration and eventually a metabolic acidosis.

The metabolic acidosis occurs later and is due to uncoupling of oxidative phosphorylation, increased fat metabolism and inhibition of the tricarboxylic acid cycle.

The metabolic acidosis tends to occur more rapidly and more commonly in children under the age of 12.

The urinary pH in aspirin overdosage is initially alkaline and then becomes acidic.

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