Sat27November0445PM 41

In chronic renal failure:

True / False

A correlation exists between falling glomerular filtration rate and rising parathyroid activity Correct

The incidence of gout is increased Incorrect answer selected

There are low levels of 25-hydroxycholecalciferol Correct

Red cell survival is reduced Correct

Blood urea levels are low Correct

Explanation

In chronic renal failure (CRF) secondary and tertiary hyperparathyroidism occur, thus there is a correlation between falling glomerular filtration rate and rising parathyroid activity.

In CRF there is failure to hydroxylate 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. The 25-hydroxylation of Vitamin D occurs in the liver and 1,25-hydroxylation occurs in the kidney.

Chronic renal failure has a high urea level and ureamia may cause coma, convulsions, flapping tremor, myoclonus, and pericarditis, etc.

Red cell survival is reduced, and red cell production is low due to reduced erythropoietin production in the kidney.

Gout is surprisingly rare despite the presence of hyperuricaemia.

Answer Statistics

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Average score: 57.11%

Times answered: 284