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Are the following true or false regarding clopidogrel?

True / False

Is a prodrug activated in the liver by the cytochrome P450 system Correct

Is a vitamin K antagonist Correct

Is a thrombin inhibitor Correct

Is a suitable alternative in patients with aspirin hypersensitivity Correct

Causes irreversible blockade of platelet ADP receptors Correct

Explanation

Clopidogrel is a thienopyridine prodrug with an active metabolite half life of eight hours. It acts by irreversibly blocking platelet ADP receptors for the life of the platelet.

It is a suitable alternative in patients who demonstrate aspirin hypersensitivity.

Reference:

Smart S, Aragola S, Hutton P. Antiplatelet agents and anaesthesia. Contin Educ Anaesth Crit Care Pain. 2007;7:157-16.

Answer Statistics

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Average score: 88.31%

Times answered: 248