Sat27November0445PM 21

Features of primary hyperaldosteronism or Conn's syndrome include:

True / False

High blood renin levels Correct

Muscle weakness Correct

Hyperkalaemia Correct

Hypertension Correct

Acidosis Correct

Explanation

In primary hyperaldosteronism, or Conn's syndrome, there is a hypokalaemic alkalosis, low renin hypertension. It is most commonly due to an adrenal adenoma, but bilateral adrenal hyperplasia may also be a cause.

Muscle weakness and tetany (associated with the alkalosis) may be a feature.

The condition is diagnosed on the basis of an elevated renin:aldosterone ratio (RAR) or an aldosterone:renin ratio (ARR).

The ARR value of an individual that is higher than the cut-off reference point indicates primary hyperaldosteronism. If the RAR ratio is used, a value lower than the cut-off reference point will also indicate primary hyperaldosteronism.

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