Mon22November1200AM 18

True / False

Is indicated for motion sickness Correct

Is metabolised by the hepatic cytochrome P450 enzymes Correct

Antagonises receptors in the chemoreceptor trigger zone (CTZ) Correct

Antagonises dopamine and muscarinic receptors Incorrect answer selected

Is a serotonin (5-HT3) receptor agonist Incorrect answer selected

Explanation

Ondansetron affects both peripheral and central receptors.

It affects neither dopamine receptors nor muscarinic receptors.

The serotonin receptors are located in the chemoreceptor trigger zone

Although ondansetron is effective for postoperative nausea and vomiting it does not have a large effect on vomiting caused by motion sickness.

Reference:

Ye JH, Ponnudurai R, Schaefer R. Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 2001;7:199-213.

Answer Statistics

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Average score: 77.13%

Times answered: 244