Mon22November0925AM 7

Which of the following pharmacokinetic models is most likely to be used for the target-controlled infusion (TCI) of propofol in paediatric patients?

(Please select 1 option)

Schnider

Marsh Incorrect answer selected

Maitre

Kataria This is the correct answer

Minto

Explanation

Kataria et al developed a three-compartmental model for propofol in children to address the over-estimation of plasma concentration found in the Marsh (adult) model when used with children.

The pharmacokinetic models used by TCI systems are used to calculate the relative sizes of the central (vascular), vessel-rich peripheral and vessel-poor peripheral compartments. The relative volumes of these compartments are different in young children when compared to adults. TCI pumps also calculate the rate of redistribution of drug between these compartments in order to calculate appropriate infusion rates to maintain plasma or effect-site levels.

Kataria, therefore, is the correct option as described above.

The Maitre model is a three-compartmental model for alfentanil TCI.

The Marsh model describes a propofol TCI model for adults; it was used in the first commercially available TCI system, the Diprifusor.

The Minto model applies to TCI remifentanil.

The Schnider model, is another adult model for propofol that incorporates age and lean body mass as co-variates.

Answer Statistics

1

19%

2

21%

3

6%

4

38%

5

18%

Times answered: 255