DIC
title: Disseminated Intravascular Coagulation (DIC) tags: #FFICM notebook: ð-FFICM type: inprogress
- [[revision-notes-in-intensive-care]]
4.3.1 Disseminated intravascular coagulation (DIC)
| Flashcard | type:basic |
|---|---|
| What is the most common cause for DIC? | Sepsis |
| What are the two main presentations of DIC? | Bleeding and Microthrombi |
| Is fibrinogen up or down in DIC? | Down |
| Is PT up or down in DIC? | Up |
| Is APTT up or down in DIC? | Up |
| Is D-Dimer up or down in DIC? | Up |
| Are platelets up or down in DIC? | Down |
| What are the three main haem things that go up in DIC? | PT / APTT / D-Dimer |
| What are the two main haem things that go down in DIC? | Fibrinogen / Platelets |
| How do you fix DIC? | Fix the underlying cause |
| What do you give to fix significant bleeding in DIC? | FFP and Platelets |
- Defined by International Society of Thrombosis and Hemostasis (ISTH) as âan acquired syndrome characterized by the intravascular activation of coagulation with loss of localization arising from different causesâ.
- Most common cause is sepsis.
- Commonly manifests clinically with bleeding, although can present with microthrombi.
- Laboratory findings include:
- Hypofibrinoginaemia
- Prolonged PT and APTT
- Raised D-dimer
- Thrombocytopaenia
- Management focuses on identification and treatment of the underlying cause, and transfusion of FFP/platelets if significant bleeding is encountered.
- Unfractionated heparin is used by some practitioners in the presence of thrombotic complications; however, its use is controversial and is not universally accepted.
| Flashcard | type:cloze |
|---|---|
| {{c1::Disseminated Intravascular Coagulation::condition}} is an acquired syndrome characterised by the {{c2::intravascular activation of coagulation::pathology}} with {{c3::loss of localisation::clause}}, arising from {{c4::different causes::cause}} |