Journal Club

Callum Taylor

2023-05-02

Origin of Study

“Many clinicians fear that post-operative ICU care may result in outcomes inconsistent with older adults’ wishes,
including admission to a nursing home or ongoing support to perform activities of daily living”

Origin of Study

“among older adults there is limited information,
regarding patient-reported experience after a post-op ICU admission.
This lack of understanding of the patient’s perception of their outcomes,
result in communication pitfalls and lead to plans inconsistent with their values

Reported Aim

“To address this knowledge gap”

Population

  1. Older adults (70+, Study Mean 76.5)
  2. High Intensity Cancer Surgery
  3. Regional Cancer Centres, Ontario, Canada,
  4. Unplanned ICU Admissions: 2007-2017

Older Patients

High Intensity Cancer Surgery

Regional Cancer Centres

Unplanned ICU Admission

  • Admitted ICU and ventilated
  • Admitted ICU after day of surgery

Exclusions

  • Patients already in nursing homes
  • Patients with previous cancer
  • or multiple cancer types

Symptom Burden

Comorbidities/Frailty

“John Hopkins Adjusted Clinical Groups (ACG) System”

ICD-10 Diagnoses -> “Adjusted Diagnostic Groups”

Second Tangent

“A patient with both:
Obstructive Chronic Bronchitis (ICD-9-CM code 491.2) and
Congestive Heart Failure (ICD-9-CM code 428.0)
will fall into only one ADG,
Chronic Medical: Unstable (ADG-11),”

Example ADGs

Allergies Asthma Likely To Recur: Progressive
Chronic Medical - Stable Dermatologic Chronic Specialty: Orthopaedic
Injuries - Minor Malignancy Psychosocial
Signs/Symptoms: Uncertain Discretionary Time Limited

Cohort: 16,650
ICU: 1,650

Symptom Burden

Symptom Burden

Secondary Outcomes:
Hospital Survivors 1 Year Mortality

Unplanned ICU: 19%

Remainder: 12%

Secondary Outcomes:
Adjuvant SACT

Unplanned ICU: 30%

Remainder: 33%

Results:
Symptoms worse…

  • Probability of moderate-severe symptom burden: 1.6x
  • Increase in symptom burden in all domains (-pain)

…but not by much

  • Probability of symptoms:
    • One Month: 6.9% vs 4.7%
    • One Year: 3.2% vs 2.3%
  • Average Global Score:
    • One Month: 20 vs 16 (/90)
    • One Year: 18 vs 12

Authors Conclusions

“…most patients do not experience a high overall symptom burden during the year after surgery.
These findings support the role of aggressive therapy among older adults after major surgery.”

Cohort:

Cohort:

Going back to original question:

“Many clinicians fear that post-operative ICU care may result
in outcomes inconsistent with older adults’ wishes,
including admission to a nursing home or ongoing support to perform activities of daily living”

Hospital Disposition (Survivors):

Outcome Unplanned ICU No Unplanned ICU
Home Independent 52% 59%
Inpatient Rehab 11.6% 2.3%
Home - Homecare 35.7% 38.1%
Impaired Independence 48% 41%

Stats: Covariates

Age Sex Income
Geographic Location Comorbidity Frailty
Cancer Site Stage Year

Prevalence of Mod-Severe Symptoms

modified log-poisson model with an autoregressive correlation structure

Symptom Trajectory Over Time

Generalised Linear mixed models with a spatial correlation structure,
and an unstructured covariance matrix

Autoregressive correlation structure

Spatial Correlation structure